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Serum sodium<135mmol/L (<120mmol/L is severe).
- Kidney problems - Addison's, renal failure, acute tubular necrosis, chronic pyelonephritis, diuretics and others
- Non-renal - diarrhoea and/or vomiting, burns, pancreatitis, trauma, fistula, small bowel obstruction, endurace sport event, heat exposure
- Oedmatous - nephrotic syndrome, heart failure, cirrhosis, renal failure
- Normovolaemic - SIADH, water overload, severe hypothyroidism, glucocorticoid deficiency
- Neuro - headache, decreased level of consciouness, cognitive impairment, personality change seizure, brain stem herniation (fixed unilateral dilated pupil, decorticate or decerebrate postuiring, respiratory arrest)
- GI - nausea, vomiting
- General - lethargy, muscle cramps and weakness
- If hypovolaemia - dry mucous membranes, tachycardia, reduced skin turgor
- If hypervolaemia - crackles, third heart sound, raised JVP, peripheral oedema, ascites
- U+Es are useful for sodium (obviously) but also assessing dehydration (urea and creatinine).
Firstly determine their hydration status. Then the most important things are:
- Urinary sodium
- Urine osmolality
The reason being the help to determine which of the causes is most likely. In hypovolaemia:
- Urinary sodium >20mmol/L - renal cause
- Urinary sodium <20mmol/L - non-renal cause
- Urine osmolality >100mOsmol/kg - SIADH
Otherwise, it must be something else. See pathophysiology.
- Hypovolaemia - isotonic saline replacement
- Normovolaemia - fluid restrict to 500ml/24h.
- Hypervolaemia - furosemide, ACE inhibitors, fluid restrict.