Antibiotics - nucleic acid synthesis inhibitors

For others, go to our page on antibiotics.

Metronidazole

It is a bactericidal agent. It is metabolised to a toxic intermediate not found in eukaryotic cells. This intermediate inhibits bacterial cell DNA synthesis and degrades exisitng DNA.

It has antibacterial properties against anaerobic bacteria and also protozoa. It an be given orally, via IV, as a topical agent or per rectum. It should not be given to pregnant women.

Side effects include GI disturbances, headache. A severe reaction will occur if taken with alcohol.