Weight gain

Epidemiology

Differential Diagnosis

• PCOS
• Endocrine - hypothyroidism, Cushing's syndrome
• Drugs - steroids

Clinical and Associated Features

• PCOS - fat, hairy, sweaty, spotty, infertile women.
• Hypothyroidism - there's a million. But since you've asked. Generalised: tiredness, lethargy, intolerance to cold; skin: dry skin, hair loss, cold peripheries; neuromuscular: intellectual slowing (poor memory, difficulty concentrating), delayed tendon reflex, carpal tunnel syndrome, puffy hands feet and face (myxoedema), eye problems; GI: [consitpation]], decreased appetite, weight gain; chest: bradycardia, pericarditis, pleural effusion; ENT: hearing loss due to fluid in middle ear, deep hoarse voice; reproductive: reduced libido, menorrhagia, then oligo-/amenorrhoea.
• Cushing's syndrome/steroid - similar symptoms. spells CUSHINGOID: Cataracts, Ulcers, Skin: striae, thinning, bruising, Hypertension/ Hirsutism/ Hyperglycemia , Infection, avascular Necrosis of the femoral head, Glycosuria, Osteoporosis, Immunosuppression, Diabetes. Others: mooooooooonface, Buffalo hump.