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This is Skunk Anansie lead singer, Skin, who wrote the song Weak. It's a good song and better than Bell's palsy.


Reduction in power of motor system.




Essentially, either you're just knackered and suffering from fatigue due to systemic illness. Neurological causes result in specific patterns of weakness, firstly differentiating between focal and local and between upper and lower motor neuron.

Clinical and Associated Features

  • Fatigue - generalised all-over weakness is due to any systemic illness.
  • Lower motor neurone (LMN) lesion - generally, this will be in the distribution of a specific nerve (e.g. wrist drop in a radial nerve palsy). Results in: wasting, reduced tone, reduced reflexes. No sensory loss in pure LMN lesion.
  • Upper motor neurone (UMN) lesion - not specific to a nerve but maybe a nerve root or part of the brain (e.g. in stroke). Results in: fasciculations, potentially wasting, increased tone, hyperreflexia (brisk reflexes).
  • Proximal muscle weakness - generalised weakness in the big muscles. This tends to happen over time. Muscle bulk depends on the aetiology.

Differential Diagnosis